Metoclopramide and prochlorperazine in radiation sickness.

Evaluation of prochlorperazine buccal tablets (Bukatel) and metoclopramide oral tablets in the treatment of acute emesis.

The dizziness associated with vertiginous disorders is often accompanied with nausea and/or vomiting. Antiemetic effect of prochlorperazine (PCZ) is diminished by its low bioavailability owing to a significant gastric and hepatic first pass effect. This effect could be further diminished by likelihood of regurgitation of nauseating patients further limiting the therapeutic effect of oral PCZ. A...

A randomized controlled trial of prochlorperazine versus metoclopramide for treatment of acute migraine.

STUDY OBJECTIVE We compare prochlorperazine 10 mg intravenously versus metoclopramide 20 mg intravenously for the emergency department (ED) treatment of acute migraine. METHODS This was a randomized, double-blind, clinical trial comparing 2 parenteral dopamine antagonists. Both drugs were administered during 15 minutes with 25 mg intravenous diphenhydramine. Pain scores on a numeric rating sc...

Comparison of metoclopramide, prochlorperazine and placebo in prevention of postoperative nausea and vomiting (PONV) following tonsillectomy in young adults.

BACKGROUND Postoperative nausea and vomiting following anaesthesia and surgery are common and can create considerable problems regarding management of patients and outcome of the surgical procedure. METHODS This study evaluates and compares the efficacy and safety of the metochlopramide to that of prochlorperazine in the prevention of postoperative nausea and vomiting after tonsillectomy in y...

Arterial Suture in Acute Radiation Sickness

Prochlorperazine in Anxiety

Seventy patients suffering from primary anxiety state were selected for this clinical trial. They were randomly assigned to Prochlorperazine (Group I) and other drugs eg., Chlordiapoxide etc. (Group II). Hamilton's anxiety scale was employed to rate the anxiety. With the 4 weeks of therapy there was significant fall in score in both the groups of patients but the fall in score is more in Group ...